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The drugs can also reduce the effectiveness of some forms of birth control, making unplanned pregnancies more likely

Efficacy and Bone Safety of Sotagliflozin 400 and 200 mg Versus Placebo in Participants with Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control (SOTA-BONE) [(accessed on 28 October 2024)]

However, as of 2024 they have been included in the World Anti-Doping Agencys monitoring program, which tracks usage patterns and examines whether the drugs provide an unfair advantage or pose health risks and they could be banned in the future.

Orlistat has traditionally been a first-line option due to its established safety profile and availability, though its modest efficacy (typically 3-5% additional weight loss beyond lifestyle intervention) and gastrointestinal side effects limit its appeal