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Retatrutide is an investigational triple receptor agonist that simultaneously activates glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors

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Drugs from Non-Snake Venom Lizard venom study yielded two approved synthetic analogs, exenatide and lixisenatide, which are used to regulate insulin secretion and suppress glucagon, thus helping to reduce body weight and regulate cardiovascular risk factors

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Additionally, the medication affects gut motility throughout the digestive system, which may contribute to constipation or altered bowel patterns that exacerbate discomfort

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Semaglutide works by mimicking a naturally occurring hormone in your body called GLP-1 (glucagon-like peptide-1)

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