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This inhibits GSK3 and prevents phosphorylation of -catenin, thereby resulting in the stabilization and accumulation of -catenin proteins

Ozempic (type 2 diabetes) tops out at 1.0 mg as the standard maintenance dose, with an optional step to 2.0 mg added in 2024

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Mechanism of Action Metformin decreases hepatic glucose production and improves hepatic insulin sensitivity but has only a modest impact on peripheral insulin-mediated glucose uptake (i.e., insulin resistance), which is likely due to a reduction in hyperglycemia, triglycerides, and free fatty acid levels (48,49)