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and 4) highlights their potential as locations for the rational design of novel allosteric modulators with the capacity to fine-tune GLP-1R responses

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A Korean study has found that probiotic strain Limosilactobacillus fermentum GB102 could enhance GLP-1 receptor agonist (RA) dulaglutide in obesity treatment. The study details that although GLP-1 RA treatments are effective for weight loss, when discontinued, weight regain is common