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June 2024 Patent Highlights: GLP-1R Agonists, Pol Inhibitors, Non-Ab PD-L1 Inhibitors, and More

The rate of antibody formation is quite high in some short-acting or non-human-homologous peptides: Lixisenatide: 69.8% antibody formation incidence Exenatide: 44% antibody formation incidence Liraglutide: 8.6% antibody formation incidence Albiglutide: 4% antibody formation incidence Dulaglutide: 1.6% antibody formation incidence While these antibodies rarely neutralize the therapeutic efficacy of the compound, they can occasionally correlate with localized skin reactions

Deshalb, so Aberle, sei es wichtig, "immer wieder zu betonen, dass die Anwendung dieser Substanzen, egal ob Tablette oder Spritze, immer medizinisch indiziert sein muss und rztlich begleitet werden soll"

Related reading: What Are GLP-1 Medications
