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Major modifications for 2025 As outlined in the 2025 Summary of Major Modifications and Explanatory Notes, the major modifications for 2025 include the following: Further examples were added to the following substance classes to help athletes and their entourage better identify prohibited substances: S0

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Pre-existing diabetic neuropathy or underlying gastric motility disorders may delay or limit complete symptom resolution after medication cessation

The vital proteins that stimulate weight loss, like Lactoferrin and IgG, are incredibly fragile

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