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Pancreatitis (inflammation of the pancreas): Symptoms may include severe upper abdominal pain that doesnt go away, vomiting, and nausea Gallbladder disease (gallstones or gallbladder inflammation): Symptoms may include sudden and intense abdominal pain, nausea, vomiting, fever and chills Kidney problems: Changes in urination (either going more or less frequently), along with swelling in feet and ankles Hypersensitivity or allergic reactions (including anaphylaxis ): Shortness of breath, itching and swelling near the injection site, dizziness Diabetic retinopathy: People with type 2 diabetes and a history of diabetic retinopathy (a complication that affects the blood vessels in the eye) may experience worsening symptoms, including blurred vision, spots, and floaters : Symptoms include fast heartbeat, shakiness, dizziness, and confusion

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All other trials retrieved 139,140,141,142,143,144,146,147 investigated cardiometabolic parameters and were included in the meta-analyses above 134,137,138

This is the receptor that meaningfully differentiates Retatrutide from existing GLP-1 and dual GLP-1/GIP therapies