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Comparing Mechanisms of Action While both GLP-1 and GLP-3 influence metabolic function, their specific mechanisms show important differences: Insulin Secretion GLP-1 powerfully stimulates insulin secretion in a glucose-dependent manner, meaning it only enhances insulin release when blood glucose is elevated

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Some are now FDA-approved for chronic weight management, including semaglutide 2.4 mg (Wegovy), tirzepatide (Zepbound), and liraglutide 3 mg (Saxenda)

Researchers are also investigating whether GLP-1 medications may affect the cells responsible for collagen production, potentially contributing to facial aging, according to a 2025 review in Endocrine