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As these medications promote weight loss and alter fluid balance, the cardiovascular system may adjust heart rate to maintain adequate cardiac output and tissue perfusion

The effect is most pronounced during dose escalation, when your body is adjusting to a new medication concentration

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When ibuprofen is necessary , several strategies can minimise risks: Take with food reduces direct gastric irritation, though Wegovy slows digestion Use the lowest effective dose typically 200-400mg for mild to moderate pain Limit duration avoid prolonged courses without medical supervision Stay well-hydrated particularly important given Wegovy's gastrointestinal effects Consider gastric protection proton pump inhibitors (PPIs) may be appropriate for extended NSAID use if recommended by a clinician based on your risk factors For over-the-counter use, ibuprofen should typically not exceed 1.2g per day (e.g., 400mg three times daily) unless advised by a healthcare professional