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Notably, just over half of patients (53.8%) taking these medications have a history of Type 2 diabetes or have an associated medical visit with their prescription, which indicates that providers are prescribing these drugs off-label

The benefit of SGLT2i therapy beyond improved glycaemic control was first reported in the EMPA-REG study which reported a reduced incidence of major adverse cardiovascular events in patients with type 2 diabetes [19]

However, high rates of weight loss carry substantial risks of muscle loss

Non-alcoholic fatty liver disease and nonalcoholic steatohepatitis NAFLD, particularly its inflammatory subtype NASH, is closely associated with obesity and T2DM [243]

Four datapoints were excluded for one cage in vehicle group due to food spillage on day 11-14