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Although previous trials of leptin receptor (LepR) agonists have failed because of leptin resistance, a LepR/GLP-1 receptor co-agonist has undergone preclinical study [78]

Kowalczyk, M

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The early results TRUMPH are certainly noteworthy: Average weight loss of 28.3% at the highest dose Nearly half of patients achieved more than 30% weight reduction Up to 86% reduction in liver fat in Phase 2 studies Around 90% of patients with fatty liver achieved resolution These are outcomes that were once thought to be achievable primarily through bariatric surgery

Skin can lose some of its stretch as fat is lost quickly, and the body has less time to produce additional collagen or adapt