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GLP-1 receptor agonists like semaglutide and tirzepatide signal the brain's appetite center, slow stomach emptying, and enhance insulin release in response to meals

1: Pharmacies can't stock enough to keep up with demand 2: Many insurance companies aren't covering these medications for weight loss When it comes to obesity, Medicare recently announced it would cover these drugs for obese patients who have cardiovascular disease

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But retatrutide may be even more effective , for several reasons: Glucagon receptor activation promotes hepatic fat oxidation Reduces liver fat accumulation more robustly Improves liver enzyme levels (ALT, AST) In a subgroup analysis of the retatrutide Phase 2 trial: Patients with suspected NAFLD showed a 70%+ reduction in liver fat content , measured by MRI-PDFF These effects surpassed the reductions seen with tirzepatide and semaglutide in comparable studies Another study showed that 93% of patients on the highest dose of retatrutide had 100% resolution of fatty liver