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Semaglutide is most effective when combined with lifestyle changes, such as a healthy diet and regular physical activity

The black-box warning is formatted within a black border found at the top of the manufacturers prescribing information document (also known as the package insert or product label)

Jumping to high doses too quickly dramatically increases nausea, vomiting, and other GI symptoms without producing faster weight loss

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However, bacterial contamination in expired multi-dose vials can cause serious infections, and peptide aggregates from degradation can potentially trigger immune responses