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Pain and cough ingredients still work, but phenylephrine may not be effective for congestion
Atta AA, Ibrahim WW, Mohamed AF, Abdelkader NF (2023a) Microglia polarization in nociplastic pain: mechanisms and perspectives

After a drug is approved, it is used by many more people in real life, including those with different health problems or who take other medications

This is vital for patients with insulin resistance or diabetes , common in thyroid disorder history
