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This finding expands on the already established role of TRPA1 channels in peripheral sensory neuron function 13 , and it is consistent with the new view that members of the Trp ion channel family participate in the control of multiple intestinal cell functions 15,16

As the disease recurs, damage to the airways and lung tissue gradually worsens, leading to a progressive decline in lung function, affecting the patients workforce and quality of life, and causing a huge social and economic burden

It effectively serves as a preventive shield, reducing the long-term burden of disease and shifting the focus of healthcare from reactive crisis management to proactive health preservation

A prespecified analysis of the FLOW trial evaluated the composite time to the first occurrence of heart failure events (including new onset or worsening heart failure that resulted in an unscheduled hospital admission or urgent visit) or CV death