glp 1 npo guidelines GLP-1 RA guidance roundup Indications for GLP-1/GIP RA Summary

Highlighting the implication of the effects of GLP-1 in adipose tissue, dopamine D1 and D4 receptor expression was decreased and correlated with GLP-1R expression in adipose tissue from patients with obesity compared to healthy controls, where targeting this pathway may have future clinical relevance [115]

Bottom line: GLP-1 (semaglutide or tirzepatide) therapy can be highly valuable for older adults when used thoughtfully with attention to pre-existing conditions, individualized dose adjustments, and proactive risk mitigation strategies

Peer review Peer review information Nature Aging thanks Ziyad Al-Aly, Yadong Huang and Olivier Rascol for their contribution to the peer review of this work

This disclosure appears in the Adverse Reactions section of Wegovy's FDA-reviewed prescribing information

[DOI] [PubMed] [Google Scholar] 91.Luo J, Feldman R, Rothenberger SD, Hernandez I, Gellad WF