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Its prolonged stability allows long-term receptor activation, essential for observing gradual changes in glucose regulation, insulin sensitivity, and metabolic signaling

Govindpani K, Turner C, Waldvogel HJ, Faull RLM, Kwakowsky A
doi: 10.1038/cdd.2016.52

For years, it was all about diet, exercise and lifestyle

that is, cholesterol is converted to bile acids in the liver, 95% bile acids are absorbed by the distal ileum and returned to the liver, and 5% bile acids are excreted in the stool
