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In addition, GLP-1 can reduce liver cholesterol accumulation by inhibiting SREBP2 and PCSK9, and reduce liver bile acid synthesis by weakening the negative feedback inhibition of bile acid after inhibiting FXR

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In this work, therapeutic inertia was observed in nearly 40% of the study population

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Conversely, as B6.SJL-Tg( Vil1 -cre)997Gum/J mice demonstrated germline deletion when Cre was expressed in male breeders, female breeders were used for Cre expression in this line