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Because the compound is extremely potent, experienced users generally recommend conservative dosing strategies

Discontinuation of GLP1RAs and tirzepatide typically results in weight regain, deterioration of glycaemic control and the loss of previous improvements in cardiometabolic markers

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Tirzepatide's dual-action approach Tirzepatide (found in Mounjaro and Zepbound) works differently by activating not one, but two hormone receptors: GLP-1 receptors (the same ones that semaglutide targets) GIP (glucose-dependent insulinotropic polypeptide) receptors This dual-action approach creates complementary effects on hunger, metabolism, and blood sugar regulation and yielding more impactful results than GLP-1 alone

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