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Several lifestyle factors can make a person more likely to experience irritability while on semaglutide: Diet and Blood Sugar Levels Semaglutide works by slowing digestion and reducing appetite, which can lead to lower calorie intake

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However, if youre starting tirzepatide/zepbound/wegovy instead, talk with your doctor about either switching to a non-oral birth control method or adding a barrier method during starting your GLP-1 and the dose-escalation windows