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GIP also activates an anti-nausea circuit in the brainstem, which helps offset some of the gastrointestinal burden created by GLP-1. GLP-1R: appetite, tolerability, and heart rate The GLP-1 arm carries appetite suppression, slower stomach emptying, most nausea, and part of the heart-rate signal

Consider your weight loss goals, budget for ongoing treatment, tolerance for potential side effects, and what your insurance covers

This can be especially relevant for people who delay treatment because they are uncomfortable with injections

After 4 weeks: Increase to 5 mg subcutaneously once a week

Preliminary insights on these effects might inform whether tirzepatide could serve dual therapeutic roles, treating both alcohol use behaviors and the complications that often accompany AUD