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Liraglutide should be used with caution if the patient has a history of thyroid cancer or a family history of medullary thyroid cancer as adverse effects, such as goitre, have been reported in trials, particularly in patients with pre-existing thyroid disease[11]

As tirzepatide promotes substantial weight reductionclinical trials such as SURMOUNT-1 demonstrated average weight loss of approximately 20.9% of body weight at the 15 mg dose in adults without diabetesthis metabolic shift can influence the hypothalamic-pituitary-ovarian axis that regulates menstruation

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There is a lack of concluded clinical trials in the literature about the specific use of GLP-1 and its analogs in PA therapeutics