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The GLP-1 R activation can phosphorylate AMPK, activating multiple downstream pathways through molecules such as p53, SIRT1, and peroxisome proliferator-activated receptor coactivator-1 (PGC1
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Deng YW, Shu YG, Sun SL

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Trial data shows mild to moderate gastrointestinal issues such as nausea, vomiting, and diarrheacommon with GLP-1 medications
