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Abstract The evidence is strong that bariatric surgery is superior to medical treatment in terms of weight loss and comorbidities in patients with severe obesity

A January 2024 study by Epic Research showed that more than half of people taking semaglutide or liraglutide (Victoza 2-Pak) who lost at least five pounds maintained their weight loss or lost more for a full year after discontinuing the medication

Ethical Statement This article is a narrative review of previously published studies and does not involve new data collection involving human or animal subjects

Happy Mammoth works through a structural repair mechanism rather than an appetite mechanism, aiming to rebuild the gut lining rather than change hunger signals

Finally, this study elucidated the immunosuppressive and neuroregenerative functions of GLP-1RA based on the "Tregs-microglia-neuron/NPC" axis theory