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The same 2023 JAMA study found that GLP-1 receptor agonists were associated with increased risk of bowel obstruction compared to other weight loss medications

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This protective mechanism involves the suppression of redox imbalance, improvement of sperm quality, and upregulation of nuclear factor erythroid 2related factor 2 (Nrf2) expression (91)

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In a recent news release, the manufacturer announced the submission of a new drug application to the US Food and Drug Administration (FDA) and a marketing authorisation application to the European Medicines Agency (EMA) for tirzepatide for the treatment of adults with type 2 diabetes [12]