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This hyper-concentrated state can cause the peptide to aggregate, the pH to shift dramatically, and chemical reactions to accelerate in the unfrozen portion

Tirzepatide requires the same cold storage

It remains unclear whether their use in a susceptible population, such as patients with both diabetes and underlying thyroid disease, might influence the risk of developing TED

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Therefore, liraglutide is administered as a once-daily subcutaneous injection, has a half-life of approximately 13 hours, which allows for steady blood concentration throughout the day and supports effective daily glycemic control