why does glp 1 cause muscle loss GLP-1 loss? How are people preventing it? : r/GLP1ResearchTalk GLP-1 Medication & Muscle Loss:

Many healthcare providers recommend pausing or reassessing GLP-1 medications during an active diverticulitis flare

However, the beneficial effects of GLP1 were limited in clinical trials of type 2 diabetic patients due to the very short halflife of GLP1, which is approximately 25 min, via degradation by the enzyme dipeptidyl peptidase 4 (DPP4) (Holst, 2019

I passionately believed in the molecule and its potential for both diseases, and I have continued to be a part of the unfolding scientific narrative surrounding GLP-1 over those 35 years

Consequently, patients with T2DM often exhibit reduced Pdx1 expression levels (Ofori et al., 2022)

Marso SP, Bain SC, Consoli A, Eliaschewitz FG, Jdar E, Leiter LA, et al