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Novo Nordisk uses recombinant DNA technology with engineered Saccharomyces cerevisiae (yeast) to produce the peptide backbone, followed by chemical modification to attach the fatty acid sidechain
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This effect is consistent with what has been observed with other GLP-1 based compounds and is thought to reflect a combination of weight-mediated reduction in vascular resistance and direct vascular effects of GLP-1 receptor activation
(2012) 7:e40156
