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Background and Aim The association between biliary disorders with weight reduction enhanced by GLP-1RAs was observed frequently, nevertheless, the relative risk of the clinically relevant cholelithiasis was not specified clearly among different GLP-1RAs

In contrast, real-world evidence suggests incremental benefits across MACE, heart failure, and renal outcomes, supporting the hypothesis that complementary mechanisms of action may translate into broader protection in clinical practice

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Materials and methods In this systematic review and meta-analysis, following PRISMA 2020 guidelines, PubMed, Embase, and Scopus were searched through 25 August 2025