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For short-acting formulations, follow specific timing: exenatide immediate-release (Byetta) should be injected within 60 minutes before morning and evening meals

According to a meta-analysis evaluating 453 trials and 21 antidiabetic treatments, oral semaglutide reduces all-cause mortality and cardiovascular death, with the lowest odds ratios (ORs) among the treatments evaluated (empagliflozin, liraglutide, extended-release exenatide, dapagliflozin, dulaglutide, lixisenatide, canagliflozin, pioglitazone, DPP-4 inhibitors, subcutaneous semaglutide, sulphonylureas) [56]

According to FDA prescribing information, headache incidence differs by product and indication