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An exploratory DEXA analysis of the STEP 1 trial found that semaglutide produced a 9.7% reduction in total lean body mass over 68 weeks alongside a 19.3% reduction in total fat mass, meaning fat was lost at roughly twice the rate of lean tissue

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The high rate of additional anti-diabetic medication use may have lead to an over-estimation of treatment effect in some of the treatment groups, such as semaglutide 3 mg

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