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Cardiovascular safety has been evaluated with both oral and subcutaneous semaglutide

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Small-scale clinical trials revealed that GLP-1 and GLP-1-based medicines may have positive effects on low-grade inflammation, blood pressure, cholesterol, and microcirculation (34)

For more than 50 years metformin has been used to control hyperglycaemia in patients with type 2 diabetes, and it is currently recommended as the first-line drug treatment along with lifestyle modification [1]

Commonly considered an undesirable off-target for molecular glue degrader programs, GSPT1 is emerging as a promising oncology target