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Demand for these three GLP-1 brands, across their various brands and formulations, has led to unprecedented levels of media attention and unsolicited celebrity endorsements that has resulted in unexpected and intermittent supply shortages

But human observational evidence is increasingly reassuring on major malformations when confounding is handled carefullyfor example, large datasets show no substantial increased risk of major congenital malformations with early exposure, and a European teratology cohort reported no increase in major birth defects vs diabetes/high-BMI comparators

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A new analysis is raising concerns about Wegovy, the blockbuster weight-loss drug, after researchers found it may carry the highest risk of a rare eye stroke that can cause sudden vision loss