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Serious AEs were reported by 7.9% (n = 10) with semaglutide, 11.0% (n = 14) with liraglutide, and 7.1% (n = 6) with placebo (Table 3)

Keep track of how you feel when starting or adjusting these medications

Choose tirzepatide for maximum results or semaglutide for best value

Do not move the vial back and forth repeatedly between the refrigerator and room temperature

Observational studies are included to provide evidence on effectiveness in broader, more heterogeneous real-world populations, to capture longer-term outcomes beyond typical RCT durations, and to assess safety signals that may be too rare to detect in RCTs