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There is some intriguing data suggesting that GIP, at least in animals, mitigates some of the adverse events that can be induced by GLP-1, says Drucker

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Weight gain occurs in 510% of tirzepatide users and does not necessarily indicate medication failureit often signals a mismatch between your genetic receptors and the drug's mechanism

If you notice any of these signs, select a spot at least one inch away from the affected area