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As such, the current evidence demonstrates association, not proven causality

Emond, M., Schwartz, G

Ozempic (Semaglutide) does not cause diverticulitis on its own, yet its most common side effects, like constipation, nausea, and slowed digestion, can mimic or worsen a flare in people who already have diverticular disease

Additionally, GLP-1 RAs exhibit neuroprotective and anti-inflammatory effects, increase Akt dephosphorylation, decrease proinflammatory factors such as TNF-, elevate neurotrophic factors like BDNF, reduce oxidative stress and microglial activation, and enhance gut-brain axis function and gut microbiota stability [176]

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