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As GLP-1 medications continue to be prescribed to millions of people worldwide, more data will accumulate on the incidence, risk factors, mechanisms, and optimal management of this side effect

However, it is still necessary to develop neuroprotective therapies for AIS to protect the brain against injury before and during reperfusion, prolong the time window for intervention, and consequently improve neurological prognosis

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Patients should ensure they consume sufficient protein, vitamins, and minerals whilst losing weight, and may benefit from referral to a registered dietitian within specialist services for tailored nutritional support

The trial will randomise patients with IIH to determine the efficacy and safety of Presendin versus placebo