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17 Additionally, activation of AMP-activated protein kinase (AMPK) by liraglutide leads to endothelial protection and angiogenesis regulated by the hypoxia inducible factor-1heme oxygenase-1 (Hif-1 HO-1) axis

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This was emphasised in the CANTOS trial, in which a monoclonal antibody targeting IL-1 in individuals with established atherosclerotic CVD and evidence of systemic inflammation reduced the risk of major adverse cardiovascular events (MACE) by 1517%, an effect that was likely to be mediated by reductions in serum CRP concentrations [80, 81]

Activating glucagon receptors encourages your body to burn more calories, which can help you reach a calorie deficit faster