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Supplementary Materials Data Availability Statement Anonymized individual participant data will be made available along with the trial protocol and statistical analysis plan

Clinical implications: Multiple companies are developing muscle-preserving therapies, suggesting this will be an active area of development

and a control group of people who continued use of non-GLP-1 receptor agonist antihyperglycemics, defined as usual care (n = 1,203,097)

The observation that a high dose of peripherally administered semaglutide and strong chemogenetic activation of PPGs suppress intake in an additive manner (Brierley et al., 2021) argues against highly convergent signalling mediating hypophagia in this context