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The result is a beneficial shift in body compositionlosing more dangerous deep fat while preserving lean muscle mass

The oral vs injection effectiveness comparison covers the evidence for tirzepatide specifically

GLP-1 agents examined in the analysis included semaglutide (Wegovy), dulaglutide (Trulicity), tirzepatide (Zepbound), exenatide (Byetta), liraglutide (Saxenda), and lixisenatide (Lyxumia)

Abbreviations AACE: American Association of Clinical Endocrinology AE: Adverse event CDS: Chinese Diabetes Society DPP-4i: Dipeptidyl peptidase-4 inhibitor ETD: Estimated treatment difference FPG: Fasting plasma glucose GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist PIONEER: Peptide Innovation for Early Diabetes Treatment SAE: Serious adverse event SF-36v2: 36-item Short Form Health Survey (Acute Version) SMPG: Self-monitored plasma glucose References Sun H, Saeedi P, Karuranga S et al (2022) IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

Notably, our previous experimental study demonstrated that DPP4 activity is closely associated with the severity of peritoneal dysfunction, primarily through the upregulation of EMT (16)