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The medication is no longer on the FDA's drug shortage list

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Evidence appraisal was informed by the Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines on the formulation of clinical practice recommendations [9, 10]

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Dipeptidyl peptidase-4 (DPP-4) inhibition Insulin is released when DPP-4 breaks down the incretin hormones glucose-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

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