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Pharmacological agents capable of inhibiting the negative regulator(s) of the signalling pathways are expected to potentiate the action of insulin and leptin and therefore be beneficial for the treatment of Type 2 diabetes and obesity

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At follow-up, due to marked hyperphagia, a switch to aripiprazole was recommended

Arent, professor and chair of the department of exercise science at the University of South Carolina

Third, although publication bias is always a concern in meta-analyses, formal assessment through funnel plots or Eggers test is not statistically reliable with fewer than ten studies, and therefore was not performed