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3 SELECT FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials Semaglutide 2.4mg over 208 weeks compared to placebo reduced the composite of cardiovascular death or worsening heart failure

[121] suggested the possible existence of synergistic weight-loss and glucose-lowering effects of semaglutide and pramlintide in two adults with T1D and comorbid obesity (without reporting significant side effects during this combination therapy)

Beyond weight loss, semaglutide improved cardiovascular health markers in trial participants

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