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These symptoms are non-specific

Ozempic: Originally for diabetes but widely used off-label for obesity

Pfizer terminated lotiglipron in October 2023 due to dose-dependent liver enzyme elevations, and subsequently discontinued danuglipron in April 2025 after a single case of potential drug-induced liver injury was identified in a dose-optimization study

It suggests that the benefits in terms of MACE, hospitalization for heart failure, and progression of chronic kidney disease (composite outcome) from SGLT2is occur independently of the use of GLP1-RAs

This central effect is a key reason why GLP-1 agonists are so effective for weight loss