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Glucagon receptor activation: Increases hepatic glucose output (managed by the concurrent insulin-sensitizing effects) Promotes thermogenesis and caloric expenditure at rest Accelerates fatty acid oxidation in the liver In research models, the net result has been a greater caloric deficit effect than with GLP-1 or dual-agonists, contributing to the significant weight-reduction percentages observed in Phase 2 trials

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Leptin activates TRPC channels to depolarize steroidogenic factor 1 (SF1) neurons in the VMH, and thus maintains energy balance and glucose homeostasis [142]

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Patients allergic to tirzepatide, with a history of medullary thyroid cancer, MEN 2 syndrome, pregnant and breastfeeding females, and children should not use tirzepatide