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Acute pancreatitis In January 2026, the UK MHRA has instructed manufacturers to update the product information for all GLP-1 and dual GIP/GLP-1 receptor agonists to highlight the potential risk of severe acute pancreatitis associated with these drugs, including rare reports of necrotizing and fatal pancreatitis [13]

Weight loss also tends to follow a dose-response pattern, meaning higher doses generally produce greater average reductions in body fat

Simon tells SELF

For a private prescription, the MHRA licence covers adults with a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related condition

Am I a good candidate for skin tightening after GLP-1