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2020;69:37OR

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"What we saw was that this group was gaining weight, and what they gained was fat." Scientists said the drug appeared to become less effective after interruption, even after the mice got back on for a second cycle and stayed on consistently for 62 days

These CVOT findings are supported by a real-world study performed in over 3 million patients with T2DM from the United States, in which patients treated with SGLT2is did not have a higher risk of any or lower amputation compared with incretins or other glucose-lowering agents [77]
