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A number of investigational new drugs targeting GLP-1R, GIPR and GDF-8 pathways are under clinical trials (Table 2)
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To determine the changes in microglial activation, IL-1 and TNF- were examined by western blotting, and the number and morphology of microglia were measured by immunofluorescence

GLP-1 receptor agonists are known to suppress appetite, which can lead to a reduced intake of essential micronutrients
