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For example, one study showed that in people with type 2 diabetes, treatment with semaglutide (1 mg weekly) causes an average loss of about 6% of body weight over 40 weeks, while treatment with tirzepatide (15 mg/week) leads to an 11% weight loss in this population

Animal studies have shown fetal harm at treatment doses

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Safety assessment of combination therapies in the treatment of obesity: Focus on naltrexone/bupropion extended release and phentermine-topiramate extended release

Risks include gastrointestinal side effects, pancreatitis, gallbladder disease, and a boxed warning for thyroid C-cell tumors