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The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo
Consistently, alanine mutations at E 6.53b decreased retatrutide-induced cAMP signaling potency by 3.6-fold for GLP-1R, 1.6-fold for GIPR and 8.3-fold for GCGR, while at E/D 7.42b , potency decreased by 71.6-fold for GIPR and 5.8-fold for GCGR (Fig
A separate genetic strategy expressed Gqcoupled designer receptors exclusively activated by designer drugs (DREADD) under the control of the Insl5 promoter, to allow chemogenetic stimulation of colonic Lcells (Lewis et al., 2020)
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more common if paired with insulin or sulfonylureas
